CJD is a rare disease of humans that affects the nervous system
and results in rapidly progressive dementia, loss of motor control, paralysis,
and death.
In addition to CJD which affects humans, other TSEs include bovine spongiform
encephalopathy (BSE, also known as "mad cow disease"), scrapie
in sheep, and chronic wasting disease (CWD) in deer and elk.
The current theory is that a normal version of the prion protein, found
in all people, is somehow converted in a diseased individual to an abnormal
form.
The World Health Organization and the U.S. Centers for Disease Control
and Prevention has found no scientific evidence that CWD can infect humans.
cdwpos
prions, disease, deer, CWD, mutant, beef, BSE, protein, cow,
transmission, eating, brains.
The recent introduction of Chronic Wasting Disease (CWD) into
the deer population in Wisconsin has raised a variety of new issues for
our state.
As representatives of the Medical Society of Milwaukee County Public Health
Committee we have recently reviewed the available literature on this issue
and sought the advice of experts on prion diseases, such as CWD.
Prions are believed to be mutant protein structures of a normal molecule
produced in neurons of all mammals, including man.
Current scientific knowledge does not allow us to definitively predict
whether CWD of deer will behave like BSE or like scrapie, a prion disease
of sheep.
12-24-00 D7
http://www.nwaonline.net/pdfarchive/2000/December/24/12-24-00
D7.pdf BELGRADE, Yugoslavia--- Prodemocracy forces claimed sweeping
victory Saturday in Serbia's parliamentary elections, declaring that they
now have a mandate to remove the last vestiges of Slobodan Milosevic's
regime in Yugoslavia's main republic.
The ultranationalist Radical Party trailed with about 8 percent in the
elections in Serbia, the larger of two republics that make up Yugoslavia.
Milosevic's allies continued to control the government of Serbia, which
accounts for more than 90 percent of Yugoslavia's population of 10 million.
ANKARA, Turkey --- After a fourday siege of prisons that left 28 dead,
Turkey's government said Saturday it has shattered a radical leftist group
operating from inside the facilities, throwing its leaders into solitary
confinement.
umich
The first experiment involves the automatic creation of 120
multi-document summaries and 308 single-document summaries from a set
of 30 clusters of related documents.
THE CONDITION known in cattle as 'mad cow disease', spongiform encephalopathies,
has been found in Britain's sparsely-scattered antelope population, the
government has admitted.
The experiment which we conducted required subjects to read a set of news
articles and write down the inter-document relationships which they observed.
In the second and third rows, the numbers of "sentence pairs"
listed speaks of distinct sentence pairs for which either one or multiple
judges observed a relationship, respectively.
The participants (six in all) were presented with a cluster of ten news
articles and four 400-word multi-document summaries (by 4 human assessors).
dir_lindquist02
Proteins are the basis of life as we know it, providing the
building blocks, the moving parts, and the energy that drives the engine.
Whitehead Director Susan Lindquist has focused on three aspects of protein
folding.
These renegade proteins, "prions" and "amyloids,"
are a second focus of Lindquist's research.
These maintain their general shapes all the time, but routinely switch
a small region, folding and refolding, to drive growth and development.
Lindquist's lab has been using simple organisms like yeast, fruit flies,
and plants, which share basic features of protein folding with mammals,
but are easier to study and manipulate.
The Lindquist lab traced the deformities that emerge under stress to many
small genetic mutations that are kept in check by Hsp90.
BSE_Flyer
http://w3.aces.uiuc.edu/AnSci/BSE/Slide_show/BSE_Flyer.pdf Mad Cow Disease (BSE: bovine spongiform encephalopathy) is
a transmittable disease originally identified in the United Kingdom in
1985.
The disease was spread by the feeding of rendered Meat and Bone Meal (MBM)
containing bovine brain and spinal cord back to cattle.
History of vCJD: BSE is now thought to be responsible for a similar disease
in humans: vCJD (variant Creutzfeldt-Jakob Disease).
The USDA and FDA monitor suspicious animals for BSE, have banned the import
of cattle from countries with BSE, have banned feeding MBM back to cattle
and have identified most of the cattle imported from the UK since the
disease was discovered and confirmed their absence of the disease.
paper_Derek_Cluck
"Mad-Cow Disease", or more properly, Bovine Spongiform
Encephalopathy (BSE), is just the most well known of a number of degenerative
neurological diseases with one thing in common--they are caused by a single
molecule, a prion.
Most surprisingly, prions are a transmissible disease causing agent, yet
have no nucleic acid genome at all; they are simply a single self replicating
protein molecule.
The vacuoles grow at an increasing rate, with the victim subject to rapidly
increasing loss of motor control, dementia, and finally death within a
year of first symptoms through subsequent infection and loss of organ
control.
Instead, it is a normal protein called PrP sup C found on the surface
membranes of all mammalian neurons in some form.
pulsenewslettervo1no 1
http://www.communitybloodservices.org/assets/pulsenewslettervo1no
1.pdf Proceeds of the event will be used to help offset the costs
incurred by the Center in providing blood and blood products to 26 hospitals
in Bergen, Passaic, Morris, Es and Hudson Counties in New Jersey as
well as Rockland and Orange counties in New York.
Warren Martin of Pompton Lakes is entertained by MECOS while donating
platelets.
Thanks to MECOS, Community Blood Service's newest "staff" member,
you can now work or be entertained at the same time you are helping those
in need by donating blood or platelets.
To make an appointment to donate blood please call (201) 251-3703.
These drives are critical in helping to alleviate the blood shortage that
traditionally takes place during the summer when many donors are away
on vacation.
A special thanks to all of our dedicated volunteer blood donors.
blood_factssheet2
Symptoms may not appear for many years after the disease process
begins, but once they do, death usually occurs within 3 to 12 months.
So far, people who have been ill with vCJD have been aged between 16 and
52 years, with most in their twenties and thirties.
However, there have been no cases of "Mad Cow" disease in Australian
cattle and there have been no cases of vCJD in Australia.
The Registry is similar to those operating in the United Kingdom and New
Zealand.
Following completion of a look back study to 1970, there are currently
440 reports on the Register.
proposal
Following highly contentious public health crises associated
with Bovine sponigorm encephalopathy ("mad cow disease" or BSE)
and dioxins and international trade disputes over beef growth hormones
and genetically-modified foods, European food safety institutions have
been undergoing a major transformation.
One of the important characteristics of food safety regulation is the
tension it produces between consumer protection and trade liberalization.
As Grace Skogstad argues, this new framework represents a partial internationalization
of food safety regulation.
Our intention is that these papers will be then made available as IES
working papers.
We may then pursue the publication of these papers as a collected volume.
vet
invention, TAMUS, gene, patent, mammals, animals, cells, effi,
diseases, resistant, cattle, TAMU College Station.
The bovine PrP gene was cloned and then modifi ed by site-directed
mutagenesis to produce a BSE-resistant form of the gene.
Transgenic animals homozygous for the mutant gene will continue to express
a copy of the prion-encoding gene, thereby not interfering with the normal
role of the polypeptide and effectively decreasing tendency for alteration
of sleep-wake cycles and circadian rhythms (as seen in knock-out mice).
TAMUS #1535 improves effi ciency in the generation of transgenic non-rodent
animals by providing methods for the use of apoptosis inhibitors in the
transformation of somatic and primordial germ cells (PGC).
· The invention provides methods and compositions for signifi cantly
increasing the number and/or proportion of viable, nuclear transfer-competent
cells from within mammalian cell populations contemplated for use in nuclear
transfer.
MadCowDisease&Insecticides
http://www.esb.utexas.edu/dr325/WC-articles/MadCowDisease&Insecticides.pdf BSE crisis in Britain put officials on the alert
They attribute both diseases to ingestion of prion protien found in contaminated
beef.
But Purdey has evidence the government's anti-parasite campaigns unleashed
a chemical holocaust for cattle -resulting in BSE, and that human CJD
is accelerated by the same chemical effects.
Disturbingly, Purdey and other brain researchers seem to have had an undue
share of unfortunate accidents.
Purdey's house was burned down and his lawyer who was working with him
on Mad Cow Disease was driven off the road by another vehicle and subsequently
died.
Environmental factors that affect the levels of metals,thei species and
protein 'sinks'caus the disease.
agr13
http://paimpact.cas.psu.edu/pdf/agr13.pdf Since the first ships made passage across mysterious oceans,
trade has ferried bounty from country to country.
Unfortunately, in addition to their treasures, these ships also carry
hidden cargo---insects, plants, animals and diseases that have the potential
to become pests to foreign lands.
Extension staff in Lehigh County, who led the way in our training, awareness
and education.
Unfortunately, little information about the virus was available to help
an increasingly alarmed public.
So, Penn State specialists began an intensive effort to educate people
about WNV.
In 1999, the plum pox virus was discovered in Pennsylvania, the first
occurrence of the disease in North America.
re0012
http://www.nhk.or.jp/strl/publica/bt/en/re0012.pdf A Scenario toward Personalized Interactive Television Services
Professor Choi, Key-Sun has been a visiting researcher at STRL since March
2002, and is scheduled to work here for one year.
This disease is called "BSE" in Japanese television news.
If you look up BSE in a dictionary, you might not find an entry if your
dictionary was published more than ten years ago.
This is because the disease was first reported in 1987.
In this case, the television company would have various news clips on
BSE archived, from which it could send several choices to be selected
by the viewer.
Typing "BSE disease" would quickly refer the user to a mad cow
disease article, but in this case, "disease" clarified what
the user intended for BSE.
